Early post‐treatment blood oxygenation level‐dependent responses to emotion processing associated with clinical response to pharmacological treatment in major depressive disorder

Autor: Rebecca J. Williams, Elliot C. Brown, Darren L. Clark, G. Bruce Pike, Rajamannar Ramasubbu
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Brain and Behavior, Vol 11, Iss 8, Pp n/a-n/a (2021)
Druh dokumentu: article
ISSN: 2162-3279
DOI: 10.1002/brb3.2287
Popis: Abstract Introduction Pre‐treatment blood oxygenation level‐dependent (BOLD) functional magnetic resonance imaging (fMRI) has been used for the early identification of patients with major depressive disorder (MDD) who later respond or fail to respond to medication. However, BOLD responses early after treatment initiation may offer insight into early neural changes associated with later clinical response. The present study evaluated both pre‐treatment and early post‐treatment fMRI responses to an emotion processing task, to further our understanding of neural changes associated with a successful response to pharmacological intervention. Methods MDD patients who responded (n = 22) and failed to respond (n = 12) after 8 weeks of treatment with either citalopram or quetiapine extended release, and healthy controls (n = 18) underwent two fMRI scans, baseline (pre‐treatment), and early post‐treatment (one week after treatment commencement). Participants completed an emotional face matching task at both scans. Results Using threshold‐free cluster enhancement (TFCE) and non‐parametric permutation testing, fMRI activation maps showed that after one week of treatment, responders demonstrated increased activation in the left parietal lobule, precentral gyrus, and bilateral insula (all P
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