The association of brainstem and motor recovery with awakening after out-of-hospital cardiac arrest

Autor: Alessandra I Cardi, Callie M Drohan, Jonathan Elmer, Clifton W Callaway, Francis X Guyette, Ankur A Doshi, Jon C Rittenberger
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Resuscitation Plus, Vol 12, Iss , Pp 100332- (2022)
Druh dokumentu: article
ISSN: 2666-5204
DOI: 10.1016/j.resplu.2022.100332
Popis: Background: Coma is common following resuscitation from cardiac arrest. Few data describe the trajectory of recovery the first days following resuscitation. The objective of this study is to describe the evolution in neurological examination during the first 5 days after resuscitation and test if subjects who go on to awaken have different patterns of early recovery. Methods: Prospective study of adult subjects resuscitated from out-of-hospital cardiac arrest. We abstracted demographic information and trained clinicians completed daily neurologic examinations using the Glasgow Coma Scale (GCS) and Full Outline of UnResponsiveness brainstem (FOUR-B) and motor (FOUR-M) scores during daily sedation interruption. The change in scores between Day 1 and Day 5 was analyzed using the Kruskal-Wallis Test and logistic regression models. The relationship of FOUR-B, FOUR-M, and GCS with time to death was estimated by fitting cox proportional hazard models. Results: FOUR-M and GCS did not differ over time (p = 0.10; p = 0.07). FOUR B increased over time (p
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