| Autor: |
Tuğba AKIN TELLİ, Nalan AKGÜL BABACAN, Özkan ALAN, Mehmet Akif ÖZTÜRK, Rahib HASANOV, Sinan KOCA, Süleyman HALİL, Eda TANRIKULU ŞİMŞEK, Tuğba BAŞOĞLU, Özlem ERCELEP, Faysal DANE, Perran Fulden YUMUK |
| Jazyk: |
English<br />Turkish |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Namık Kemal Tıp Dergisi, Vol 10, Iss 1, Pp 74-79 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2587-0262 |
| DOI: |
10.4274/nkmj.galenos.2021.52714 |
| Popis: |
Aim:DR-70 is a newly developed immunoassay that detects fibrin degradation products in blood. We aimed to evaluate ability of DR-70 in monitoring treatment response in advanced gastrointestinal (GI) cancers.Materials and Methods:We prospectively enrolled patients with advanced GI cancers treated with different lines of systemic therapies. Imaging studies, DR-70 and conventional tumor markers [carcinoembryonic antigen (CEA), carbohydrate antigen (CA) 19-9] were analyzed at baseline and on the third month of treatment.Results:A total of 142 patients diagnosed with colorectal (52.1%), esophago-gastric (32.4%) and pancreaticobiliary cancer (15.5%) were enrolled. Most patients were getting first-line treatment (56.3%). Second blood sampling was performed in 57% of patients. Among patients with esophago-gastric cancer, DR-70 response correlated well with treatment response (p=0.007) and low baseline DR-70 level was significantly associated with longer overall survival (p=0.02). There was a positive but weak correlation between pre-treatment DR-70 and CEA levels (p=0.03, r=0.244) in patients with colorectal cancer, while a moderate positive correlation was present between pre-treatment DR-70 and CA 19-9 levels in esophago-gastric and pancreaticobiliary cancers (p=0.01, r=0.402 and p=0.04, r=0.515, respectively). More than 25% reduction in DR-70 concentration was associated with better overall and progression-free survival.Conclusion:DR-70 is a strong predictor of treatment response and survival, particularly in esophago-gastric cancer. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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