Autor: |
Rosy Sultana, Md Tarikul Islam, Golam Sarower Bhuyan, Suprovath Kumar Sarker, Farjana Akther Noor, Mohabbat Hossain, Mamunur Rashid, Redwan Rahmat, K. Zaman, Mst. Noorjahan Begum, Zahid Hassan, Muhammad Manjurul Karim, Firdausi Qadri, Kaiissar Mannoor |
Jazyk: |
angličtina |
Rok vydání: |
2021 |
Předmět: |
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Zdroj: |
International Journal of Infectious Diseases, Vol 104, Iss , Pp 482-490 (2021) |
Druh dokumentu: |
article |
ISSN: |
1201-9712 |
DOI: |
10.1016/j.ijid.2020.12.081 |
Popis: |
Objectives: To determine IgG immune responses and hepatitis E virus (HEV) viral load, and to explore the associations with pregnancy. Methods: A total of 121 HEV-infected women (57 pregnant, 64 non-pregnant) were analysed. Quantitative reverse transcription PCR (RT-qPCR) was done for 78 HEV IgM-positive patients to determine viral load, and Sanger sequencing was performed for 62 HEV-RNA-positive patients to confirm genotyping. ELISA was conducted to determine HEV antibody and avidity indices. Results: The HEV genotype was identified as variant 1. Significant negative correlations were observed between log HEV copy number and log hepatitis E virus IgG antibody index in the late acute phase of jaundice for both pregnant women (r = −0.7971, p = 0.0002) and non-pregnant women (r = −0.9117, p = 0.0002). Pregnant women had significantly higher serum log viral copy numbers and lower IgG antibody indices than non-pregnant women in the late acute phase of HEV-induced jaundice (p = 0.0196 and p = 0.0303, respectively). Moreover, pregnant women with acute HEV hepatitis had higher cross-reactive IgG antibodies compared to the non-pregnant women (p = 0.0017). Five patients with HEV hepatitis died, of whom four were pregnant. Conclusions: Pregnancy might be associated with higher viral loads and a lower IgG response in the HEV-induced late acute phase of jaundice. |
Databáze: |
Directory of Open Access Journals |
Externí odkaz: |
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