| Autor: |
Sittampalam Rajendra, Shakthivel Vaishnavi, Nadarasa Hamsavakini, Rajendra Nalini, Mahalingam Aravinthan, Paramanathan Shathana |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
Endocrine and Metabolic Science, Vol 15, Iss , Pp 100166- (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2666-3961 |
| DOI: |
10.1016/j.endmts.2024.100166 |
| Popis: |
Introduction: Diabetes mellitus (DM) poses a significant global public health challenge, affecting approximately 10.2 % of adults by 2030. Insulin Resistance (IR) is an impaired or subnormal biologic response to insulin stimulation of target tissues. IR alters the mechanisms involved in lipid metabolism in the adipose tissue and liver leading to dyslipidaemia and accumulation of fat in the liver (NAFLD). Non-alcoholic fatty liver disease (NAFLD) has an estimated global prevalence of 25 %. NAFLD is identified frequently on ultrasonography examination of the abdomen of patients with DM because of associated insulin resistance and obesity. Methodology: This study conducted at TH Jaffna aimed to assess the lipid profile status of type 2 diabetic patients undergoing treatment, and its association with Insulin Resistance and NAFLD. Result: In a cross-sectional analytical study of 112 diabetic patients (average age 58.26 years, 61.6 % female), a significant prevalence of insulin resistance (70.5 %) and NAFLD (77.7 %) was observed, with comorbid dyslipidaemia in 51.7 % of patients. No gender-based difference in lipid profile parameters was found. Total cholesterol, LDL, and TG were mostly within non dyslipidaemic levels, while HDL levels were low. There is a statistically significant association (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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