Diagnostic utility of fractional exhaled nitric oxide in prolonged and chronic cough according to atopic status

Autor: Takamitsu Asano, Masaya Takemura, Kensuke Fukumitsu, Norihisa Takeda, Hiroya Ichikawa, Hisatoshi Hijikata, Yoshihiro Kanemitsu, Takehiro Uemura, Osamu Takakuwa, Hirotsugu Ohkubo, Ken Maeno, Yutaka Ito, Tetsuya Oguri, Atsushi Nakamura, Akio Niimi
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Zdroj: Allergology International, Vol 66, Iss 2, Pp 344-350 (2017)
Druh dokumentu: article
ISSN: 1323-8930
DOI: 10.1016/j.alit.2016.08.015
Popis: Background: Cough-variant asthma (CVA) and cough-predominant asthma (CPA) are the major causes of persistent cough in Japan. The utility of fractional exhaled nitric oxide (FeNO) measurement in the differential diagnosis of persistent cough has been reported, but the influence of atopic status, which is associated with higher FeNO levels, on the diagnostic utility of FeNO has been unknown. Methods: We retrospectively analyzed 105 non-smoking patients with prolonged and chronic cough that were not treated with corticosteroids and anti-leukotrienes. Results: CPA was diagnosed in 37 patients, CVA in 40, and non-asthmatic cough (NAC) in 28. FeNO levels were significantly higher in the CPA [35.8 (7.0–317.9) ppb] and CVA [24.9 (3.1–156.0) ppb] groups than in the NAC group [18.2 (6.9–49.0) ppb] (p
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