Biochemical and genetic biomarkers associated with nicotine dependence in Mexican smokers

Autor:	Gissela Borrego‐Soto, Yadira Xitlalli Perez‐Paramo, Francisco Hernández‐Cabrera, Fatima Miroslaba Alvarado‐Monroy, Gilberto Borrego, Alejandro Robles‐Zamora, Philip Lazarus, Augusto Rojas‐Martinez
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	genetic polymorphisms nicotine nicotine dependence nicotine metabolism nicotine metabolism ratio Therapeutics. Pharmacology RM1-950
Zdroj:	Pharmacology Research & Perspectives, Vol 11, Iss 5, Pp n/a-n/a (2023)
Druh dokumentu:	article
ISSN:	2052-1707
DOI:	10.1002/prp2.1142
Popis:	Abstract Cigarette smoking remains an important health concern and is still a leading cause of preventable mortality. Nicotine is the substance responsible for sustained tobacco use and dependence. Identification of biomarkers underlying nicotine dependence behavior is important to identify people at risk for this dependence. In the present study, we identified biochemical and genetic biomarkers of nicotine dependence detected by the Fagerström Test for Nicotine Dependence (FTDN) in Mexican smokers. The nicotine metabolites nicotine‐N′‐oxide, trans‐3′‐hydroxycotinine‐glucuronide (3HC‐O‐Gluc), and nicotine‐N‐Gluc (Gluc) were useful to differentiate nicotine‐dependent from non‐dependent subjects (p
Databáze:	Directory of Open Access Journals
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