Choroidal involvement in Rosai-Dorfman disease successfully treated with cobimetinib

Autor:	Chiara Giuffrè, Giuseppe Giuffrè
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	choroidal biopsy choroidal thickness cobimetinib mek inhibitor rosai-dorfman disease Ophthalmology RE1-994
Zdroj:	Indian Journal of Ophthalmology, Vol 68, Iss 9, Pp 2051-2053 (2020)
Druh dokumentu:	article
ISSN:	0301-4738 1998-3689
DOI:	10.4103/ijo.IJO_1359_20
Popis:	Rosai- Dorfman disease (RDD) is a rare systemic pseudo-lymphomatous disorder with unknown etiology. No guidelines exist regarding its management and treatment when the disease is progressing. Choroidal involvement in RDD has rarely been reported and has often been misdiagnosed. We describe a case of a 64-year-old male diagnosed with RDD by means of choroidal biopsy, successfully treated with a MEK inhibitor, namely Cobimetinib, and its follow-up over 5 years, with good final anatomical and functional results. This is the first reported case of RDD diagnosed with an intraocular biopsy performed on a non-enucleated globe, thus preserving the integrity and function of the eye. This case emphasizes the need for a choroidal biopsy when the diagnosis is not straightforward and the starting of targeted therapy to retain a good visual function.
Databáze:	Directory of Open Access Journals
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