A Case Report of Ischemic Stroke in a Patient with Metastatic Gastric Cancer Secondary to Treatment with the Vascular Endothelial Growth Factor Receptor-2 Inhibitor Ramucirumab

Autor:	Michael E. Christiansen, Timothy Ingall, Edward C. Lew, Ramesh K. Ramanathan, Harshita R. Paripati
Jazyk:	angličtina
Rok vydání:	2016
Předmět:	Gastric cancer Ischemic stroke Adverse effects Angiogenesis inhibitors Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	Case Reports in Oncology, Vol 9, Iss 2, Pp 317-320 (2016)
Druh dokumentu:	article
ISSN:	1662-6575
DOI:	10.1159/000446695
Popis:	Ramucirumab is an antiangiogenesis agent targeting the vascular endothelial growth factor receptor-2 (VEGFR-2), approved to treat advanced gastric and colon cancer. In clinical trials, it was shown to cause a small increase in arterial thromboembolism compared to placebo, including cerebral and myocardial ischemia, which was not statistically significant. Detailed case reports are lacking and we here present one of the first case reports of stroke secondary to ramucirumab-induced in situ thrombosis.
Databáze:	Directory of Open Access Journals
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