A Panel of High Resolution Melting (HRM) Technology-Based Assays with Direct Sequencing Possibility for Effective Mutation Screening of EGFR and K-ras Genes
Autor: | D. A. M. Heideman, F. B. Thunnissen, M. Doeleman, D. Kramer, H. M. Verheul, E. F. Smit, P. E. Postmus, C. J. L. M. Meijer, G.A. Meijer, P. J. F. Snijders |
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Jazyk: | angličtina |
Rok vydání: | 2009 |
Předmět: | |
Zdroj: | Cellular Oncology, Vol 31, Iss 5, Pp 329-333 (2009) |
Druh dokumentu: | article |
ISSN: | 1570-5870 1875-8606 |
DOI: | 10.3233/CLO-2009-0489 |
Popis: | Background: Increasing data from clinical trials support EGFR and K-ras mutation status as predictive markers of tumour response to EGFR-targeted therapies. Consequently, rapid and reliable mutation screening assays are demanded to guide rational use of EGFR-targeted therapies. |
Databáze: | Directory of Open Access Journals |
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