Utility of VerifyNow to assess the immediate pharmacodynamic response of chewed and swallowed aspirin: comparison with aggregometry

Autor:	Kevin P. Bliden, Parshotam Kundan, Danielle Kraft, Rueshil Parekh, Sahib Singh, Aravind D. Babu, Anika P. Shah, Udaya S. Tantry, Paul A. Gurbel
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	Acetylsalicylic acid platelet aggregation thromboxane B2 VerifyNow aspirin test Diseases of the blood and blood-forming organs RC633-647.5
Zdroj:	Platelets, Vol 35, Iss 1 (2024)
Druh dokumentu:	article
ISSN:	09537104 1369-1635 0953-7104
DOI:	10.1080/09537104.2023.2298352
Popis:	VerifyNow (VN) test is a less laborious method to assess pharmacodynamics (PD) compared to light transmittance aggregometry (LTA). VN assay has not been used to study the immediate PD effects of acetylsalicylic acid (ASA). Ten healthy volunteers were randomly assigned to a single 162 or 650 mg dose of chewed and swallowed ASA. Pharmacodynamic and pharmacokinetic measurements were performed at baseline and serially up to 60 min after ASA administration. Onset by VN was 20 ± 7 min with 162 mg and 13 ± 7 min with 650 mg ASA (p = .07). Onset by 1 mM AA-induced PA was 13 ± 12 min with 162 mg and 7 ± 3 min with 650 mg ASA (p=NS). VN correlated with AA-induced PA (r = 0.80, p
Databáze:	Directory of Open Access Journals
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