The efficacy and tolerability of paroxetine (adepress), an antidepressant from a group of selective serotonin reuptake inhibitors, in psychoautonomic syndrome within anxiety-depressive disorders
| Autor: | T G Voznesenskaya, N M Fokina |
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| Jazyk: | ruština |
| Rok vydání: | 2012 |
| Předmět: | |
| Zdroj: | Неврология, нейропсихиатрия, психосоматика, Vol 4, Iss 2, Pp 56-60 (2012) |
| Druh dokumentu: | article |
| ISSN: | 2074-2711 2310-1342 |
| DOI: | 10.14412/2074-2711-2012-384 |
| Popis: | The objective of the investigation was to study the clinical efficacy, tolerability, and side effects of adepress in patients with mild and moderate anxiety-depressive disorders and psychoautonomic syndrome. The investigation included 30 outpatients, of whom 29 completed it. Monotherapy with adepress (paroxetine) was used in a dose of 10—20 mg/day for 8 weeks. Adverse reactions were observed in one-third of the patients within the first 2 weeks of therapy. Their intensity was not more than 3 visual analog scale scores. They required neither dose adjustment nor drug discontinuation and ceased spontaneously. After 8 weeks, the positive effect of the therapy was noted in all the patients. Adepress was found to show a high clinical efficacy and antidepressant, anxiolytic, and autonomic stabilizing activities. Adepress also normalized the sleep-wake cycle and diminished tension headache. |
| Databáze: | Directory of Open Access Journals |
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