Bronchiolitis obliterans organizing pneumonia : Experience at three hospitals in Riyadh
| Autor: | Alsaghir Abdullah, Al-Mobeireek Abdullah, Al-Jahdali Hamdan, Al-Eithan Abdulsalam, Al-Otair Hadil, Al-Dayel Fouad |
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| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Předmět: | |
| Zdroj: | Annals of Saudi Medicine, Vol 27, Iss 1, Pp 32-35 (2007) |
| Druh dokumentu: | article |
| ISSN: | 0256-4947 0975-4466 |
| Popis: | Background: Because reports of bronchiolitis obliterans organizing pneumonia (BOOP) are lacking from the Middle East, we conducted a retrospective review of of all histopathologically proven cases of BOOP over a 10-year period at three tertiary care hospitals in Riyadh and describe the clinical features and outcome. Methods: Charts at the three hospitals were searched using a specific code for BOOP or cryptogenic orga-nizing pneumonia (COP). Lung specimens had to show histological proof of BOOP with a compatible clinical picture. Chest radiographs and high-resolution CT scans were reviewed. Results: Twenty cases of biopsy-proven BOOP had well-documented clinical and radiographic data. There were 11 males and 9 females (mean age, 58 years; range, 42-78). The clinical presentation of BOOP was acute or subacute pneumonia-like illness with cough (85%), fever (70%) dyspnea, (85%) and crackles (80%). The most frequent radiological pattern was a bilateral alveolar infiltrate. The most common abnormality on pulmonary function testing (n=14) was a restrictive pattern (11 patients). Most patients (70%) had no underlying cause (idio-pathic BOOP). Other associations included thyroid cancer, rheumatoid arthritis, syphilis and Wegner′s granulo-matosis. Ten patients (50%) had a complete response to steroids, 6 (30%) had a partial response and 3 (15.8%) with secondary BOOP had rapid progressive respiratory failure and died. Conclusion: The clinical presentation of BOOP in our patients is similar to other reported series. A favorable outcome occurs in the majority of cases. However, BOOP may occasionally be associated with a poor prognosis, particularly when associated with an underlying disease. |
| Databáze: | Directory of Open Access Journals |
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