Dynamic actin cycling through mitochondrial subpopulations locally regulates the fission–fusion balance within mitochondrial networks

Autor: Andrew S. Moore, Yvette C. Wong, Cory L. Simpson, Erika L. F. Holzbaur
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Zdroj: Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/ncomms12886
Popis: Mitochondria are dynamic organelles that can undergo fission and fusion. Here the authors identify a novel pathway in which actin dynamically assembles in an Arp2/3- and formin-dependent manner around a subset of cellular mitochondria, promoting localized Drp1-dependent fission and impeding fusion.
Databáze: Directory of Open Access Journals