Impact of radiotherapy to the primary tumor on the efficacy of pembrolizumab for patients with advanced urothelial cancer: A preliminary study

Autor: Hiroshi Fukushima, Toshiki Kijima, Shohei Fukuda, Shingo Moriyama, Sho Uehara, Yosuke Yasuda, Hajime Tanaka, Soichiro Yoshida, Minato Yokoyama, Yoh Matsuoka, Kazutaka Saito, Nobuaki Matsubara, Noboru Numao, Yasuyuki Sakai, Takeshi Yuasa, Hitoshi Masuda, Junji Yonese, Yukio Kageyama, Yasuhisa Fujii
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Cancer Medicine, Vol 9, Iss 22, Pp 8355-8363 (2020)
Druh dokumentu: article
ISSN: 2045-7634
DOI: 10.1002/cam4.3445
Popis: Abstract Radiotherapy plus immune checkpoint inhibitors can potentially induce synergistic antitumor immune responses. However, little clinical evidence is established regarding their combination therapy. Here, we aimed to assess whether radiotherapy to the primary tumor impacts on the efficacy of pembrolizumab in advanced urothelial cancer. We retrospectively reviewed 98 advanced urothelial cancer patients receiving pembrolizumab in a second‐ or later‐line setting using our multicenter cohort. Patients were categorized according to a history of radiotherapy to the primary tumor: patients previously exposed to radiotherapy to the primary tumor (Radiotherapy group, 17 patients [17%]) and those not (Nonradiotherapy group, 81 patients [83%]). The associations of radiotherapy to the primary tumor with objective response and survival were evaluated. The Radiotherapy group showed a significantly higher objective response ratio than did the Non‐radiotherapy group (65% vs 19%; P
Databáze: Directory of Open Access Journals
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