A Search for Dual Action HIV-1 Reverse Transcriptase, Bacterial RNA Polymerase Inhibitors
| Autor: | Agata Paneth, Tomasz Frączek, Agnieszka Grzegorczyk, Dominika Janowska, Anna Malm, Piotr Paneth |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: | |
| Zdroj: | Molecules, Vol 22, Iss 11, p 1808 (2017) |
| Druh dokumentu: | article |
| ISSN: | 1420-3049 22111808 |
| DOI: | 10.3390/molecules22111808 |
| Popis: | Using molecular modeling approach, potential antibacterial agents with triazole core were proposed. A moderate to weak level of antibacterial activity in most of the compounds have been observed, with best minimal inhibitory concentration (MIC) value of 0.003 mg/mL, as shown by the 15 against S. epidermidis. Studied compounds were also submitted to the antifungal assay. The best antifungal activity was detected for 16 with MIC at 0.125 and 0.25 mg/mL against C. albicans and C. parapsilosis, respectively. |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
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