The Nuclear Receptor PXR in Chronic Liver Disease

Autor: Katia Sayaf, Ilaria Zanotto, Francesco Paolo Russo, Daniela Gabbia, Sara De Martin
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Cells, Vol 11, Iss 1, p 61 (2021)
Druh dokumentu: article
ISSN: 11010061
2073-4409
DOI: 10.3390/cells11010061
Popis: Pregnane X receptor (PXR), a nuclear receptor known for modulating the transcription of drug metabolizing enzymes and transporters (DMETs), such as cytochrome P450 3A4 and P-glycoprotein, is functionally involved in chronic liver diseases of different etiologies. Furthermore, PXR activity relates to that of other NRs, such as constitutive androstane receptor (CAR), through a crosstalk that in turn orchestrates a complex network of responses. Thus, besides regulating DMETs, PXR signaling is involved in both liver damage progression and repair and in the neoplastic transition to hepatocellular carcinoma. We here summarize the present knowledge about PXR expression and function in chronic liver diseases characterized by different etiologies and clinical outcome, focusing on the molecular pathways involved in PXR activity. Although many molecular details of these finely tuned networks still need to be fully understood, we conclude that PXR and its modulation could represent a promising pharmacological target for the identification of novel therapeutical approaches to chronic liver diseases.
Databáze: Directory of Open Access Journals
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