A computational systems approach identifies synergistic specification genes that facilitate lineage conversion to prostate tissue

Autor: Flaminia Talos, Antonina Mitrofanova, Sarah K. Bergren, Andrea Califano, Michael M. Shen
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Zdroj: Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/ncomms14662
Popis: The identification of master regulator genes that may be manipulatedin vitro to regulate reprogramming has been difficult. Here, the authors use a computational systems approach to identify three genes (FoxA1, Nkx3.1and the androgen receptor) that can reprogramme fibroblasts to prostate tissue.
Databáze: Directory of Open Access Journals