Autor: |
Vijay Patil, Amit Joshi, Vanita Noronha, Atanu Bhattacharjee, Sachin Dhumal, M V Chandrakanth, Ashay Karpe, Vikas Talreja, Arun Chandrasekharan, Siddharth Turkar, Nikhil Pande, Anant Ramaswamy, Kumar Prabhash |
Jazyk: |
angličtina |
Rok vydání: |
2018 |
Předmět: |
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Zdroj: |
South Asian Journal of Cancer, Vol 7, Iss 4, Pp 249-253 (2018) |
Druh dokumentu: |
article |
ISSN: |
2278-330X |
DOI: |
10.4103/sajc.sajc_233_17 |
Popis: |
Background: Quality-adjusted time without toxicity (Q-TWiST) and quality of life (QOL) are indicators of benefit provided by different chemotherapy regimens. Methods: This was a prospective study, in which adult head-and-neck (H and N) cancer patients, treated with metronomic chemotherapy were enrolled. The Functional Assessment of Cancer Therapy-General H and N (FACT-G and H and N) version 4 pro formas were self-administered before the start of chemotherapy and then at 2, 4, and 6 months. FACT QOL and Q-TWiST analysis were then performed. Results: There was an improvement in the social well-being (P = 0.370), emotional well-being (P = 0.000), functional well-being (P = 0.000), H and N cancer subscale (P = 0.001), FACT H and N trial outcome index (P = 0.000), FACT G-total score (P = 0.000), and FACT H and N total score (P = 0.000) with palliative chemotherapy. The QTWiST value for a utility score of 0.25 for toxicity and relapse state was 145.93 days. Conclusion: Metronomic chemotherapy is associated with improvement in QOL and has a low duration of time spent in toxicity state. |
Databáze: |
Directory of Open Access Journals |
Externí odkaz: |
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