Inhibition of Corneal Neovascularization by Topical and Subconjunctival Tigecycline
| Autor: | Sertan Goktas, Ender Erdogan, Rabia Sakarya, Yasar Sakarya, Mustafa Yılmaz, Muammer Ozcimen, Nejat Unlukal, Ismail Alpfidan, Fatih Tas, Erkan Erdogan, Abdulkadir Bukus, Ismail Senol Ivacık |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: | |
| Zdroj: | Journal of Ophthalmology, Vol 2014 (2014) |
| Druh dokumentu: | article |
| ISSN: | 2090-004X 2090-0058 |
| DOI: | 10.1155/2014/452685 |
| Popis: | Objective. To investigate the effects of topical and subconjunctival tigecycline on the prevention of corneal neovascularization. Materials and Methods. Following chemical burn, thirty-two rats were treated daily with topical instillation of 1 mg/mL tigecycline (group 1) or subconjunctival instillation of 1 mg/mL tigecycline (group 3) for 7 days. Control rats received topical (group 2) or subconjunctival (group 4) 0.9% saline. Digital photographs of the cornea were taken on the eighth day after treatment and analyzed to determine the percentage area of the cornea covered by neovascularization. Corneal sections were analyzed histopathologically. Results. The median percentages of corneal neovascularization in groups 1 and 3 were 48% (95% confidence interval (CI), 44.2–55.8%) and 33.5% (95% CI, 26.6–39.2%), respectively. The median percentages of corneal neovascularization of groups 1 and 3 were significantly lower than that of the control group (P=0.03 and P |
| Databáze: | Directory of Open Access Journals |
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