Determination of Reference Intervals for Platelet Parameters using Sysmex XN-1000 among South Indian Population

Autor: Santiago Gnanadeepam, Packiaraj Selvajothi, MuthuPonnuswamy Sumathy, Subramanian Kuzhali, Anandan Sujatha
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Journal of Clinical and Diagnostic Research, Vol 16, Iss 9, Pp EC36-EC40 (2022)
Druh dokumentu: article
ISSN: 2249-782X
0973-709X
DOI: 10.7860/JCDR/2022/54863.16899
Popis: Introduction: Reference intervals are important for interpretation of clinical laboratory tests. The platelet parameters are recently reported newer haematological parameters and serve as clinically valuable biomarkers. It provides further information on platelet morphology and proliferation kinetics. The lack of information from manufacturers about the geographical reference ranges for the Complete Blood Count (CBC) parameters highlights the need for laboratories to establish reference intervals. Aim: To determine the reference interval for platelet parameters using Sysmex XN-1000 haematology analyser in South Indian population. Materials and Methods: This retrospective record-based study was carried out from July 2021 to September 2021 and the data was retrieved from a continuous 12-month period (November 2018-October 2019) in the Haematology Laboratory at a tertiary care dental hospital, Chennai, Tamil Nadu, India. The data of CBC parameters were retrieved from the Sysmex XN-1000 analyser and a total of 1,883 reports labelled as negative/unflagged were included in the study. The reference intervals for platelet parameters which include Mean Platelet Volume (MPV), Platelet Distribution Width (PDW), Platelet Large Cell Ratio (P-LCR) and Plateletcrit (PCT) for male and female subjects were compared using the Mann-Whitney U-test. Kruskal-Wallis test was used to compare between the different age groups using Statistical Package for the Social Sciences (SPSS) version 24.0 software. Results: The data for the platelet parameters are shown as median, with statistically significant difference in the reference interval for all the parameters with gender (p
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