Prognostic factors of worse outcome for hospitalized COVID-19 patients, with emphasis on chest computed tomography data: a retrospective study

Autor: Adham do Amaral e Castro, Patrícia Yokoo, Eduardo Kaiser Ururahy Nunes Fonseca, Jessyca Couto Otoni, Sarah Lustosa Haiek, Hamilton Shoji, Rodrigo Caruso Chate, Andrea Z Pereira, Marcos Roberto Gomes de Queiroz, Marcelo Costa Batista, Gilberto Szarf
Jazyk: English<br />Portuguese
Rok vydání: 2022
Předmět:
Zdroj: Einstein (São Paulo), Vol 20 (2022)
Druh dokumentu: article
ISSN: 2317-6385
DOI: 10.31744/einstein_journal/2022ao6953
Popis: ABSTRACT Objective: To evaluate anthropometric and clinical data, muscle mass, subcutaneous fat, spine bone mineral density, extent of acute pulmonary disease related to COVID-19, quantification of pulmonary emphysema, coronary calcium, and hepatic steatosis using chest computed tomography of hospitalized patients with confirmed diagnosis of COVID-19 pneumonia and verify its association with disease severity. Methods: A total of 123 adults hospitalized due to COVID-19 pneumonia were enrolled in the present study, which evaluated the anthropometric, clinical and chest computed tomography data (pectoral and paravertebral muscle area and density, subcutaneous fat, thoracic vertebral bodies density, degree of pulmonary involvement by disease, coronary calcium quantification, liver attenuation measurement) and their association with poorer prognosis characterized through a combined outcome of intubation and mechanical ventilation, need of intensive care unit, and death. Results: Age (p=0.013), body mass index (p=0.009), lymphopenia (p=0.034), and degree of pulmonary involvement of COVID-19 pneumonia (p
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