New connections of medication use and polypharmacy with the gut microbiota composition and functional potential in a large population

Autor:	Anna Larsson, Ulrika Ericson, Daniel Jönsson, Mariam Miari, Paschalis Athanasiadis, Gabriel Baldanzi, Louise Brunkwall, Sophie Hellstrand, Björn Klinge, Olle Melander, Peter M. Nilsson, Tove Fall, Marlena Maziarz, Marju Orho-Melander
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	Gut microbiota Gut metabolic modules Medications Polypharmacy Population cohort Shotgun metagenomics Medicine Science
Zdroj:	Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Druh dokumentu:	article
ISSN:	2045-2322
DOI:	10.1038/s41598-024-71571-4
Popis:	Abstract Medication can affect the gut microbiota composition and function. The aim of this study was to investigate connections between use of common non-antibiotic medicines and the gut microbiota composition and function in a large Swedish cohort (N = 2223). Use of 67 medications and polypharmacy (≥ 5 medications), based on self-reported and prescription registry data, were associated with the relative abundance of 881 gut metagenomic species (> 5% prevalence) and 103 gut metabolic modules (GMMs). Altogether, 97 associations of 26 medications with 40 species and of four medications with five GMMs were observed (false discovery rate
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/0e3e15c5c80a4e85b6e46a8dc63097ef Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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