| Autor: |
Orfeas Liangos, Sophie Domhan, Christian Schwager, Martin Zeier, Peter E Huber, Francesco Addabbo, Michael S Goligorsky, Lynn Hlatky, Bertrand L Jaber, Amir Abdollahi |
| Jazyk: |
angličtina |
| Rok vydání: |
2010 |
| Předmět: |
|
| Zdroj: |
PLoS ONE, Vol 5, Iss 10, p e13658 (2010) |
| Druh dokumentu: |
article |
| ISSN: |
1932-6203 |
| DOI: |
10.1371/journal.pone.0013658 |
| Popis: |
Cardiac surgery with cardiopulmonary bypass (CS/CPB) is associated with increased risk for postoperative complications causing substantial morbidity and mortality. To identify the molecular mechanisms underlying CS/CPB-induced pathophysiology we employed an integrative systems biology approach using the whole blood transcriptome as the sentinel organ.Total RNA was isolated and globin mRNA depleted from whole blood samples prospectively collected from 10 patients at time points prior (0), 2 and 24 hours following CS/CPB. Genome-wide transcriptional analysis revealed differential expression of 610 genes after CS/CPB (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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