Insights into SARS-CoV-2: Small-Molecule Hybrids for COVID-19 Treatment

Autor: Maria Luisa Navacchia, Caterina Cinti, Elena Marchesi, Daniela Perrone
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Molecules, Vol 29, Iss 22, p 5403 (2024)
Druh dokumentu: article
ISSN: 1420-3049
DOI: 10.3390/molecules29225403
Popis: The advantages of a treatment modality that combines two or more therapeutic agents with different mechanisms of action encourage the study of hybrid functional compounds for pharmacological applications. Molecular hybridization, resulting from a covalent combination of two or more pharmacophore units, has emerged as a promising approach to overcome several issues and has also been explored for the design of new drugs for COVID-19 treatment. In this review, we presented an overview of small-molecule hybrids from both natural products and synthetic sources reported in the literature to date with potential antiviral anti-SARS-CoV-2 activity.
Databáze: Directory of Open Access Journals
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