| Autor: |
Daniele Fernandes de Aguiar, Eliana Nogueira C de Barros, Guilherme Sousa Ribeiro, Patricia Brasil, Maria Paula Gomes Mourao, Kleber Luz, Francisco Hideo Aoki, Andre Ricardo Ribas Freitas, Guilherme Amaral Calvet, Eduardo Oliveira, Bianca F Branco, Ariane Abreu, Brigitte Cheuvart, Adrienne Guignard, Melanie de Boer, Ana Claudia Duarte, Maria Beatriz Borges, Tatiana Guimarães de Noronha |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
International Journal of Infectious Diseases, Vol 108, Iss , Pp 443-453 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
1201-9712 |
| DOI: |
10.1016/j.ijid.2021.04.062 |
| Popis: |
Objectives: To estimate the incidence of dengue infection across geographically distinct areas of Brazil. Methods: This prospective, household-based, cohort study enrolled participants in five areas and followed them up for up to 4 years (2014–2018). Dengue seroprevalence was assessed at each scheduled visit. Suspected dengue cases were identified through enhanced passive and active surveillance. Acute symptomatic dengue infection was confirmed through reverse-transcriptase quantitative polymerase chain reaction in combination with an antigenic assay (non-structural protein 1) and serology. Results: Among 3300 participants enrolled, baseline seroprevalence was 76.2%, although only 23.3% of participants reported a history of dengue. Of 1284 suspected symptomatic dengue cases detected, 50 (3.9%) were laboratory-confirmed. Based on 8166.5 person-years (PY) of follow-up, the incidence of laboratory-confirmed symptomatic infection (primary endpoint) was 6.1 per 1000 PY (95% confidence interval [CI]: 4.5, 8.1). Incidence varied substantially in different years (1.8–7.4 per 1000 PY). The incidence of inapparent primary dengue infection was substantially higher: 41.7 per 1000 PY (95% CI: 31.1, 54.6). Conclusions: Our findings, highlighting that the incidence of dengue infection is underestimated in Brazil, will inform the design and implementation of future dengue vaccine trials. Clinical trial registration: NCT01751139 |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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