Viruses Causing Aseptic Meningitis: A Tertiary Medical Center Experience With a Multiplex PCR Assay

Autor: Mohammed A. Aldriweesh, Edi A. Shafaay, Saud M. Alwatban, Obeid M. Alkethami, Faisal N. Aljuraisi, Mohammad Bosaeed, Naif Khalaf Alharbi
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Frontiers in Neurology, Vol 11 (2020)
Druh dokumentu: article
ISSN: 1664-2295
DOI: 10.3389/fneur.2020.602267
Popis: Background: Central nervous system (CNS) infection is associated with high rates of morbidity and mortality, and despite advancements in molecular testing, aseptic meningitis remains challenging to diagnose. Aseptic meningitis cases are often underreported worldwide, which impacts the quality of patient care. Therefore, we aimed to assess the results of BioFire® FilmArray® meningitis/encephalitis (ME) PCR panel, clinical characteristics, and etiologies of aseptic meningitis patients.Methods: From January 2018 to January 2020, all pediatric and adult patients in a large tertiary medical center who underwent lumbar puncture and cerebrospinal fluid (CSF) testing by a ME multiplex PCR panel and who fit the aseptic meningitis definition were retrospectively reviewed.Results: Data were reviewed from 1,607 patients; 240 met the inclusion criteria (54.6% males; 68.8%
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