Utility of prognostic scores in predicting short-term mortality in patients with acute-on-chronic liver failure

Autor: Talaat Zakareya, Mohamed Akl, Shereen Shibl, Mohamed El-Mazaly, Wael Abdel-Razek
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Egyptian Liver Journal, Vol 12, Iss 1, Pp 1-10 (2022)
Druh dokumentu: article
ISSN: 2090-6226
DOI: 10.1186/s43066-022-00183-2
Popis: Abstract Background Acute-on-chronic liver failure (ACLF) is a distinct syndrome associated with high short-term mortality. Early identification of patients at high risk is essential to determine emergency for transplantation and decide and prioritize the need for intensive care unit (ICU). We aimed to evaluate the performance of the different prognostic scores in the prediction of in-hospital mortality in patients with ACLF. A total of 249 patients with ACLF were included and followed till discharge from the hospital. Univariate and Cox regression analyses were used to assess the performance of liver-specific (Child-Pugh and MELD) and ACLF prognostic scores (CLIF-C OF, CLIF-SOFA, CLIF-C AD, CLIF-C ACLF) in the prediction of in-hospital mortality. Results Patients were mostly males (71.1%) with a mean age of 53.9 ± 12.8 years. The etiology of pre-existing liver disease was HCV in 57.8%. Sepsis was the most common precipitating factor (49.8%) and the mortality rate was 74.3%. In univariate analysis, all scores were significantly higher in the deceased group (P
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