| Autor: |
Ivana Savić, Goran Nikolić, Ivan Savić, Vladimir Banković |
| Jazyk: |
angličtina |
| Rok vydání: |
2008 |
| Předmět: |
|
| Zdroj: |
Chemical Industry and Chemical Engineering Quarterly, Vol 14, Iss 4, Pp 261-264 (2008) |
| Druh dokumentu: |
article |
| ISSN: |
1451-9372 |
| Popis: |
This paper presents the experimental results for the simultaneous spectrophotometric determination of two active components in nasal solutions. The resolution of two-component mixtures of timazolin and phenylephrine has been accomplished by using partial least-squares. The method comprised of the absorptivity measurement in a nasal solution at wavelengths of 265 and 272 nm, respectively. Notwithstanding the presence of two components and their high degree of spectral overlap, they have been determined simultaneously with high accuracy and precision, with no interference, rapidly and without resorting to extraction procedures using non aqueous solvents. This method was tested and validated for various parameters according to ICH guidelines. The results demonstrated that the procedure is accurate, precise and reproducible (relative standard deviation |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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