DETERMINATION OF RIVASTIGMINE HYDROTARTRATE RESIDUES ON PHARMACEUTICAL MANUFACTURING EQUIPMENT SURFACES BY HPLC AND LUMINESCENCE METHODS
| Autor: | A. V. Yegorova, G. A. Fedosenko, Yu. V. Scrypynets, I. I. Leonenko, G. V. Maltsev, V. P. Antonovich |
|---|---|
| Jazyk: | English<br />Russian<br />Ukrainian |
| Rok vydání: | 2017 |
| Předmět: | |
| Zdroj: | Vìsnik Odesʹkogo Nacìonalʹnogo Unìversitetu: Hìmìâ, Vol 22, Iss 1(61), Pp 67-78 (2017) |
| Druh dokumentu: | article |
| ISSN: | 2304-0947 2414-5963 |
| DOI: | 10.18524/2304-0947.2017.1(61).94713 |
| Popis: | Highly sensitive HPLC methods of determination of rivastigmine hydrotartrate trace amounts for cleaning of the pharmaceutical equipment have been proposed. The developed methods have been validated on the following parameters: specificity, linearity, precision, limit of detection and limit of quantification. The calibration curves were linear over the concentration range of 0,5-50,0 μg / ml (HPLC) and 0,5-20,0 μg / ml (Lum), the detection limits are 0,38 μg / ml and 0,48 μg / ml respectively. The effectiveness of the method of sampling is 83%. It is found that these methods allow to obtain comparable results. Luminecsent method in comparison with the HPLC has the following advantages: less labor intensity, rapidity and lower reagent consumption. |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|