| Autor: |
Nayana Fonseca Vaz, Julia Fadini Margon, Bruna Damasio Moutinho, Michele Harriz Braga, Claudia Megumi Tani, Regiane Saraiva de Souza Melo Alengar, Lisa Rodrigues da Cunha Saud, Denise Cerqueira Paranaguá Vezozzo, Marta Deguti, Natally Horvat, Eduardo Luiz Rachid Cançado, Flair Jose Carrilho, Aline Lopes Chagas, Débora Terrabuio |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Annals of Hepatology, Vol 24, Iss , Pp 100502- (2021) |
| Druh dokumentu: |
article |
| ISSN: |
1665-2681 |
| DOI: |
10.1016/j.aohep.2021.100502 |
| Popis: |
Background and Aims: Hepatocellular carcinoma (HCC) occurrence is rare in autoimmune hepatitis (AIH) and data about its characteristics are still scarce. The aims of this study were to describe HCC prevalence and risks factors in AIH patients in a tertiary referral hospital. Methods: Retrospective cohort of AIH patients followed from 2003 to 2019. The hazard ratios (HR) and their respective 95% confidence intervals (95%CI) were estimated using simple Cox regression. A multivariate regression model was fitted using relevant covariates for HCC occurrence. Results: Among 355 AIH patients, 84.5% were female, 85% AIH-1, 65% with cirrhosis and mean age at AIH diagnosis of 27±18yr. Sixteen cases of HCC were diagnosed (4.5%), all of them in cirrhotic patients, 81.3% female, mean age of 49±20yr, 83% overweight (BMI 34±5kg/m2) and 3 with associated steatohepatitis. The pooled incidence rate for HCC was 3.2 per 100 patient-years. The pooled incidence of HCC in patients with cirrhosis at AIH diagnosis was 4.5 per 100 patient-years. The median time between AIH diagnosis and HCC was 9 years (1-42). At univariate analysis the factors associated with HCC risk were age at diagnosis of AIH (HR,1.05; 95%CI,1.02-1.08; p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
