Prevalence of low folate deficiency after wheat flour supplementation – should we still measure serum folate?

Autor: Alejandro Godoy, Aldo Hugo Tabares
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: Hematology, Transfusion and Cell Therapy, Vol 40, Iss 4, Pp 305-309 (2018)
Druh dokumentu: article
ISSN: 2531-1379
DOI: 10.1016/j.htct.2018.03.007
Popis: Objectives: To determine the frequency of folic acid deficiency in consecutive serum folate determinations and to determine whether there was a significant decrease in serum folate deficiency after folate was added to wheat flour. Methods: A retrospective descriptive observational study was performed of consecutive folate measurements at the Hospital Privado Universitario, Cordoba, Argentina. Results: Two cohorts were analyzed: 1197 folate measurements between 2001 and 2008 (before supplementation) and 3335 folate measurements from 2009 to 2014 (after supplementation). Folate deficiency was found in 84/1197 (7%) subjects in the pre-supplementation group and in 58/3335 (1.73%) after supplementation. The prevalence of folate deficiency was 12% between 2001 and 2003 when folate was not added to flour compared to 4% in 2004–2007 (p-value
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