The Lipodystrophy Syndrome in HIV-Infected Children under Antiretroviral Therapy: A First Report from the Central Africa

Autor: Honoré Kalombayi Tshamala, Loukia Aketi, Pierre Manianga Tshibassu, Mathilde Bothale Ekila, Eric Musalu Mafuta, Patrick Kalambayi Kayembe, Michel Ntetani Aloni, Joseph Diayisu Shiku
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: International Journal of Pediatrics, Vol 2019 (2019)
Druh dokumentu: article
ISSN: 1687-9740
1687-9759
DOI: 10.1155/2019/7013758
Popis: Background. Despite the high prevalence of the HIV/AIDS, few studies focused on the prevalence of lipodystrophy in pediatric HIV patients on antiretroviral therapy (ARV) in sub-Saharan African countries. The aim of this study was to assess the prevalence and to identify the risk factors of metabolic disorders related to ARV therapy in this population. Methods. A cross-sectional study was completed in Kinshasa, the Democratic Republic of Congo. HIV-infected children aged between six and 18 years on ARV were consecutively recruited. For each case, two control children (one non-HIV infected child and one HIV-infected antiretroviral therapy-naïve child) were also recruited. Results. 80 HIV-infected on ARV therapy children (group 1), 80 noninfected children (group 2) and 65 HIV-infected antiretroviral therapy-naïve children (group 3) were recruited. The frequency of lipoatrophy was not statistically different between group 1 (16.3%) and group 3 (21.5%). A significantly higher proportion of lipohypertrophy, hypercholesterolemia, and lactic acidosis was noted in children of group 1, compared to the controls (p0.05). Conclusion. Lipohypertrophy, hypercholesterolemia, and lactic acidosis emerge as a frequent metabolic disorders due to ARV therapy.
Databáze: Directory of Open Access Journals
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