Acquired platelet dysfunction in newly diagnosed myeloma

Autor:	Joshua Mortimer, Nicola Gray, Michael Desborough, Peter Baker, Jaimal Kothari, Toby Eyre
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	bleeding disorders multiple myeloma platelet aggregation Diseases of the blood and blood-forming organs RC633-647.5
Zdroj:	eJHaem, Vol 2, Iss 1, Pp 17-19 (2021)
Druh dokumentu:	article
ISSN:	2688-6146 38127644
DOI:	10.1002/jha2.152
Popis:	Abstract This is a case of an unexpected and dramatic bleeding complication in a patient post‐bone marrow biopsy performed for investigation of an IgA paraprotein with the results confirming multiple myeloma. Subsequent investigations were suggestive of an acquired platelet disorder indicated by abnormal platelet light aggregometry readings. It was observed that the impaired platelet aggregation corrected on reduction of the paraprotein load following commencement of antimyeloma treatment and plasma exchange. This case is of significant clinical relevance as it highlights a risk factor for serious complication in patients undergoing procedures in those with untreated plasma cell dyscrasias.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/0df1c381276446b594bcd2aea1174c4b Zobrazit plný text záznamu Plný text View record in DOAJ