Racial differences in measures of glycemia in the Vitamin D and Type 2 Diabetes (D2d) Study: a secondary analysis of a randomized trial
| Autor: | Samuel Dagogo-Jack, Erin S LeBlanc, Richard E Pratley, Neda Rasouli, Anastassios G Pittas, Jason Nelson, Ranee Chatterjee, Mary K Rhee, Cyrus V Desouza, Lisa M Neff, Anne M Peters, Daniel S Hsia |
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| Jazyk: | angličtina |
| Rok vydání: | 2024 |
| Předmět: | |
| Zdroj: | BMJ Open Diabetes Research & Care, Vol 12, Iss 1 (2024) |
| Druh dokumentu: | article |
| ISSN: | 2023-0036 2052-4897 |
| DOI: | 10.1136/bmjdrc-2023-003613 |
| Popis: | Introduction Understanding how race may influence the association between A1c and glycemia can improve diabetes screening. We sought to determine whether, for a given A1c level, glucose levels during an oral glucose tolerance test (OGTT) differed by race.Research design and methods From data collected at 22 US clinical sites, we conducted a cross-sectional study of concurrently measured A1c and OGTT and observational longitudinal follow-up of the subset with high-risk pre-diabetes. Numerical integration methods were used to calculate area under the glycemic curve (AUCglu) during OGTT and least squares regression model to estimate A1c for a given AUCglu by race, controlling for potential confounders.Results 1016 black, 2658 white, and 193 Asian persons at risk of diabetes were included in cross-sectional analysis. Of these, 2154 with high-risk pre-diabetes were followed for 2.5 years. For a given A1c level, AUCglu was lower in black versus white participants. After adjustment for potential confounders, A1c levels for a given AUCglu quintile were 0.15–0.20 and 0.02–0.19 percentage points higher in black and Asian compared with white participants, respectively (p |
| Databáze: | Directory of Open Access Journals |
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