STATINS AND URSODEOXYCHOLIC ACID: COOPERATION OR NEUTRALITY?

Autor:	I. N. Grigorieva, Y. M. Pozdnyakov
Jazyk:	English<br />Russian
Rok vydání:	2016
Předmět:	статины урсодезоксихолевая кислота желчнокаменная болезнь неалкогольная жировая болезнь печени неалкогольный стеатогепатит гиперхолестеринемия Therapeutics. Pharmacology RM1-950 Diseases of the circulatory (Cardiovascular) system RC666-701
Zdroj:	Рациональная фармакотерапия в кардиологии, Vol 5, Iss 6, Pp 51-54 (2016)
Druh dokumentu:	article
ISSN:	1819-6446 2225-3653
DOI:	10.1234/1819-6446-2009-6-51-54
Popis:	Results of combined therapy of gallstone disease (GSD), non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH) and hypercholesterolemia (HCE) with statins and ursodeoxycholic acid (UDCA) are analyzed. In GSD statin therapy was often accompanied with reduction of bile lithogenicity but did not always accelerate stone litholysis under their combination with UDCA. Statin induced liver injuries are often observed in NAFLD and NASH, adjuvant UDCA therapy shown positive effect on inflammatory and histological liver parameters in these diseases. Serum lipid levels in patients with HCE were reduced most effectively with statin combined with UDCA. Combined therapy with statin and UDCA is recommended in patient with HCE and chronic liver diseases.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/0defd67051ff4d2683d99a106c112162 Zobrazit plný text záznamu View record in DOAJ