Metabolic and renal changes in patients with chronic hepatitis C infection after hepatitis C virus clearance by direct‐acting antivirals

Autor:	Riccardo Nevola, Luca Rinaldi, Letizia Zeni, Ferdinando C Sasso, Pia C Pafundi, Barbara Guerrera, Aldo Marrone, Mauro Giordano, Luigi E Adinolfi
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	direct‐acting antivirals estimated glomerular filtration rate insulin resistance low‐density lipoprotein cholesterol serum cholesterol serum glucose Diseases of the digestive system. Gastroenterology RC799-869
Zdroj:	JGH Open, Vol 4, Iss 4, Pp 713-721 (2020)
Druh dokumentu:	article
ISSN:	2397-9070
DOI:	10.1002/jgh3.12324
Popis:	Abstract Background and Aim The impact of hepatitis C virus (HCV) clearance by direct‐acting antiviral agents (DAAs) on HCV‐related extrahepatic manifestations is not well known. We evaluated the effect of viral clearance on metabolic and renal parameters. Methods In this prospective study, HCV patients who achieved a sustained virologic response (SVR) by DAAs were evaluated before, at the end, and 24 weeks after treatment for glycemic (serum glucose and insulin, HOMA‐IR, HOMA‐β, and HOMA‐S) and lipid (serum cholesterol, triglycerides, low‐density lipoprotein [LDL], high‐density lipoprotein) metabolism and renal function (serum creatinine, estimated glomerular filtration rate [eGFR]). Results A total of 343 consecutive HCV patients were evaluated. At 24 weeks of post‐follow‐up, an increase in body mass index (BMI) was observed (P
Databáze:	Directory of Open Access Journals
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