| Autor: |
Maria Facadio Antero, M.D., Bhuchitra Singh, M.D., M.P.H, M.S., Apoorva Pradhan, B.A.M.S., M.P.H., Megan Gornet, M.D., William G. Kearns, Ph.D., Valerie Baker, M.D., M.P.P., Mindy S. Christianson, M.D. |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
F&S Reports, Vol 2, Iss 1, Pp 36-42 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2666-3341 |
| DOI: |
10.1016/j.xfre.2020.11.005 |
| Popis: |
Objective: To determine whether in vitro fertilization (IVF) with preimplantation genetic testing for aneuploidy (PGT-A) is cost effective to achieve a live birth compared with IVF alone in fresh donor oocyte cycles. Design: Theoretical cost-effectiveness study. Setting: Not applicable. Patient(s): None. Intervention(s): Comparison between the cost of IVF with PGT-A vs. IVF alone to achieve a live birth. The model analyzed a hypothetical single fresh oocyte donor IVF cycle with PGT-A vs. IVF alone and followed the progression of a single embryo through the different decision nodes. Cost estimates assigned to each clinical event were based on data obtained from the literature and institutional costs. Main Outcome Measure(s): Cost per live birth. Result(s): In the base-case analysis, IVF with PGT-A was not cost effective in fresh donor oocyte cycles when compared with IVF alone to achieve a live birth. The cycles using PGT-A cost an additional $6,018.66. The incremental cost-effectiveness ratio was found to be $119,606.59 per additional live birth achieved with IVF with PGT-A. Monte Carlo simulations demonstrated that IVF with PGT-A was not cost effective in nearly all iterations. Conclusion(s): PGT-A in fresh donor oocyte IVF cycles is not cost effective compared with IVF alone over a wide range of probabilities and costs. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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