| Autor: |
Agata Kolano, Anna Pejas, Szymon Markowiak, Marta Wardęszkiewicz, Wiktoria Jabłońska, Amelia Kasprzak, Maciej Świercz, Monika Truchta, Aleksandra Mańkowska |
| Jazyk: |
English<br />Spanish; Castilian<br />Polish<br />Russian<br />Ukrainian |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
Journal of Education, Health and Sport, Vol 51 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2391-8306 |
| DOI: |
10.12775/JEHS.2024.51.014 |
| Popis: |
Introduction and purpose: Endometrial cancer [EC] is the most common gynecological cancer in developed countries and its incidence is increasing worldwide. Obesity is a prominent risk factor associated with its incidence and progression. The aim of study: The article aims to provide a thorough explanation of the mechanisms through which obesity can contribute to the development of EC. Additionally, it emphasizes the crucial role of combating excess adipose tissue as a significant component of cancer prevention specifically targeting endometrial cancer. Material and method: The literature review applied standard criteria and focused on PubMed articles using keywords: Endometrial cancer, Obesity, Mortality, Prevention, Pathogenesis Description of the State of Knowledge: Obesity significantly impacts EC development and prognosis, particularly in Type I cases. It modifies adipose tissue metabolism, affecting the release of various substances linked to tumor growth and mortality risk.The relative risks escalate with increasing BMI. Following an EC diagnosis, higher BMI, especially ≥40, significantly associates with increased overall mortality risk. On a preventive front, exercise showcases its potential in reducing EC risk by moderating insulin and estrogen levels. Summary: These findings underscore the critical role of obesity in both EC development and prognosis, emphasizing the potential for preventive measures. Without proactive measures, the worldwide obesity epidemic will persist, exerting a substantial effect on EC occurrences. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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