| Autor: |
Fehintola V. Ajogbasile, Adeyemi T. Kayode, Paul E. Oluniyi, Kazeem O. Akano, Jessica N. Uwanibe, Benjamin B. Adegboyega, Courage Philip, Oluwagboadurami G. John, Philomena J. Eromon, George Emechebe, Finimo Finimo, Nnenna Ogbulafor, Nma Jiya, Uche Okafor, Jose Ambe, Robinson D. Wammanda, Stephen Oguche, Olugbenga A. Mokuolu, Akintunde Sowunmi, Onikepe A. Folarin, Christian T. Happi |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Malaria Journal, Vol 20, Iss 1, Pp 1-9 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
1475-2875 |
| DOI: |
10.1186/s12936-021-03734-x |
| Popis: |
Abstract Background Malaria remains a public health burden especially in Nigeria. To develop new malaria control and elimination strategies or refine existing ones, understanding parasite population diversity and transmission patterns is crucial. Methods In this study, characterization of the parasite diversity and structure of Plasmodium falciparum isolates from 633 dried blood spot samples in Nigeria was carried out using 12 microsatellite loci of P. falciparum. These microsatellite loci were amplified via semi-nested polymerase chain reaction (PCR) and fragments were analysed using population genetic tools. Results Estimates of parasite genetic diversity, such as mean number of different alleles (13.52), effective alleles (7.13), allelic richness (11.15) and expected heterozygosity (0.804), were high. Overall linkage disequilibrium was weak (0.006, P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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