| Autor: |
Monireh Hoseinzadeh, Majid Jadidi, Hadi Hasanzadeh, Tahereh Khani, Shoka Shahryari, Shima Saeedi |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Journal of Kerman University of Medical Sciences, Vol 29, Iss 2, Pp 112-122 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2008-2843 |
| DOI: |
10.22062/jkmu.2022.91888 |
| Popis: |
Background: Sonodynamic therapy (SDT) may be a new hopeful non-invasive method for cancer treatment, which incorporates a combination of low-intensity ultrasound and a sonosensitive chemical. The goal of this study was to evaluate the effect of dual-frequency sonication (1 and 3 MHz) and injected Hematoporphyrin encapsulated in mesoporous silica nanoparticles (HP-MSNs) as a sensitizer in the treatment of mice grafted with breast adenocarcinoma.Methods: In this research, one hundred and thirty-two female mice with grafted breast adenocarcinoma were separated into 22 groups including control, sham, 4 groups of sonication 1 or 3 MHz (1 and 2 W/cm2), and 16 groups of SDT with Hematoporphyrin (HP) and HP-MSNs (2.5 and 5 mg/kg). The tumor growth factors and tumor grading were used to assess the treatment management.Results: The results indicate that dual-frequency sonication has a delayed effect on tumor growth. The required time of T5 to the initial volume in all groups of SDT with HP (5 mg/kg) was greater than that in the control group (P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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