Cyclooxygenase-1-selective inhibitor SC-560
| Autor: | Charles D. Loftin, Tonglei Li, Kathryn L. Theiss, Sihui Long |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: | |
| Zdroj: | Acta Crystallographica Section E, Vol 65, Iss 2, Pp o360-o360 (2009) |
| Druh dokumentu: | article |
| ISSN: | 16005368 1600-5368 |
| DOI: | 10.1107/S1600536809001779 |
| Popis: | In the title compound, 5-(4-chlorophenyl)-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazole (SC-560), C17H12ClF3N2O, a COX-1-selective inhibitor, the dihedral angles between the heterocycle and the chlorobenzene and methoxybenzene rings are 41.66 (6) and 43.08 (7)°, respectively. The dihedral angle between the two phenyl rings is 59.94 (6)°. No classic hydrogen bonds are possible in the crystal, and intermolecular interactions must be mainly of the dispersion type. This information may aid the identification of dosage formulations with improved oral bioavailability. |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|