Iron metabolism and chronic inflammation in IgA nephropathy

Autor:	Zhang-yu Tian, Zhi Li, Ling Chu, Yan Liu, Jin-rong He, Yu Xin, Ai-mei Li, Hao Zhang
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	IgA nephropathy iron metabolism chronic inflammation ferroptosis treatment Diseases of the genitourinary system. Urology RC870-923
Zdroj:	Renal Failure, Vol 45, Iss 1 (2023)
Druh dokumentu:	article
ISSN:	0886022X 1525-6049 0886-022X
DOI:	10.1080/0886022X.2023.2195012
Popis:	AbstractIgA nephropathy (IgAN), an immune-mediated chronic inflammatory kidney disease, is the most common primary glomerular disease in Asia, especially in China and Japan. The pathogenesis of IgAN is complex, and the main cause of IgAN is explained by the ‘multiple hit’ theory, which states that the deposition of immune complexes in renal mesangial cells induces chronic inflammation that leads to kidney damage. Chronic inflammation is associated with iron metabolism, which also plays an essential role in the pathogenesis, progression, diagnosis and prognosis of IgAN. Overall, this review aimed to explore the application of iron metabolism in IgAN by systematically elaborating the relationship between iron metabolism and chronic inflammation in IgAN to speculate on the possible diagnostic and therapeutic significance of iron metabolism indicators in IgAN.
Databáze:	Directory of Open Access Journals
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