Copper-Catalyzed Synthesis of Axially Chiral Biaryls with Diaryliodonium Salts as Arylation Reagents

Autor:	Ji-Wei Zhang, Shao-Hua Xiang, Shaoyu Li, Bin Tan
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	NOBIN BINAM arylation sigmatropic rearrangement copper-catalysis Organic chemistry QD241-441
Zdroj:	Molecules, Vol 26, Iss 11, p 3223 (2021)
Druh dokumentu:	article
ISSN:	1420-3049
DOI:	10.3390/molecules26113223
Popis:	NOBIN and BINAM derivatives harboring biaryl frameworks are recognized as a class of important atropisomers with versatile applications. Here, we present an efficient synthetic route to access such compounds through copper-catalyzed domino arylation of N-arylhydroxylamines or N-arylhydrazines with diaryliodonium salts and [3,3]-sigmatropic rearrangement. This reaction features mild conditions, good substrate compatibility, and excellent efficiency. The practicality of this protocol was further extended by the synthesis of biaryl amino alcohols.
Databáze:	Directory of Open Access Journals
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