Perlman Syndrome with Deletion of DIS3L2 Gene

Autor: Salameh K, Viswanathan B, Nawaz Z, Habboub L, Tomerak A, Pattuvalappil R
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Research and Reports in Neonatology, Vol Volume 10, Pp 89-93 (2020)
Druh dokumentu: article
ISSN: 1179-9935
Popis: Khalil Salameh,1 Brijroy Viswanathan,1 Zafar Nawaz,2 Lina Habboub,1 Ahmed Tomerak,1 Rajesh Pattuvalappil1 1Department of Pediatrics and Neonatology, Al Wakra Hospital, Hamad Medical Corporation, Al Wakra, Qatar; 2Department of Cytogenetics and Molecular Cytogenetics Laboratory, Hamad Medical Corporation, Doha, QatarCorrespondence: Khalil SalamehDepartment of Pediatrics and Neonatology, Al Wakra Hospital, Hamad Medical Corporation, Al Wakra, QatarTel +974 40114258Email Ksalameh@hamad.qaAbstract: Perlman syndrome is a rare genetic disorder with autosomal recessive inheritance. It is caused by deletion of the DIS3L2 gene on the long arm of chromosome 2. Though more than 30 cases have been reported in the literature with clinical features of the syndrome, very few cases have identified underlying genetic defects. The clinical features of Perlman syndrome have similarities with those of Beckwith–Wiedemann syndrome (BWS), prune belly syndrome (PBS) and Simpson–Golabi–Behmel syndrome (SGBS1). Affected patients have macrosomia, dysmorphic features, hypotonia, laxity of abdominal wall, cryptorchidism, renal anomalies and risk of development of Wilm’s tumour. Here we report a neonate with typical clinical features of Perlman syndrome, with deletion of DIS3L2 gene confirmed by array comparative genomic hybridization (aCGH).Keywords: DIS3L2, Perlman syndrome, prune belly syndrome, Wilm’s tumour
Databáze: Directory of Open Access Journals
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