Influence of Hydroxyapatite Content on Physical and Rheological Properties of Chitosan-based Scaffold
| Autor: | Luka Dornjak, Fabio Faraguna, Anamarija Rogina |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2024 |
| Předmět: | |
| Zdroj: | Tehnički Glasnik, Vol 18, Iss 2, Pp 215-223 (2024) |
| Druh dokumentu: | article |
| ISSN: | 1846-6168 1848-5588 |
| DOI: | 10.31803/tg-20230912143145 |
| Popis: | Chitosan-based scaffolds offer significant potential in tissue engineering and regenerative medicine. Whilst exhibiting great bio-regenerative and biocompatible properties, their mechanical properties remain quite poor. The presented research is focused on the modification of macroporous chitosan scaffolds with various amounts of bioactive ceramics (hydroxyapatite) and its influence on the physical and rheological properties of the composite scaffold. Chitosan/hydroxyapatite composite scaffolds with a highly porous microstructure have been prepared by suspending hydroxyapatite (HAp) particles into the chitosan matrix. According to SEM imaging, homogeneous dispersion of the inorganic phase in a chemically-crosslinked chitosan matrix had been achieved. The obtained composite scaffolds exhibited lower swelling capacity with respect to pure chitosan after 24 h of incubation in Hanks’ balanced salt solution. Rheological measurements show an increase in storage and loss modulus indicating an improvement in mechanical properties under shear stress. Furthermore, no significant change in loss factor (tanδ) was observed indicating no change in composite viscoelastic properties with an increase in HAp content. |
| Databáze: | Directory of Open Access Journals |
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