Infrared Assisted Production of 3,4-Dihydro-2(1H)-pyridones in Solvent-Free Conditions
| Autor: | René Miranda, Francisco J. Pérez, Gabriel A. Arroyo, Joel O. Martínez, Hortensia Rodríguez, M. Olivia Noguez, Osnieski Martín, Margarita Suárez, Vanessa Marcelino |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: | |
| Zdroj: | International Journal of Molecular Sciences, Vol 12, Iss 4, Pp 2641-2649 (2011) |
| Druh dokumentu: | article |
| ISSN: | 12042641 1422-0067 |
| DOI: | 10.3390/ijms12042641 |
| Popis: | A green approach for the synthesis of a set of ten 4-aryl substituted-5-alcoxy carbonyl-6-methyl-3,4-dihydro-2(1H)-pyridones using Meldrum’s acid has been devised, the absence of solvent and the activation with infrared irradiation in addition to a multicomponent protocol are the main reaction conditions. The transformations proceeded with moderated yields (50–75%) with a reasonable reaction rate (3 h). It is worth noting that two novel molecules of the new class of the bis-3,4-dihydropyridones were also obtained. In addition, a comparison without the use of infrared irradiation was performed. |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|