Synthesis of novel 2-amino-5-arylazothiazol derivatives and their biological impacts: Assessment of toxicity and antioxidant enzymes activities

Autor:	Mohamed Ezzat Khalifa, Mahmoud Abdel-Halim Mohamed, Noura Homoud Alshehri
Jazyk:	angličtina
Rok vydání:	2015
Předmět:	2-aminothiazole chalcone imine pyrazole azo coupling biological activities. Chemical engineering TP155-156 Biochemistry QD415-436
Zdroj:	Macedonian Journal of Chemistry and Chemical Engineering, Vol 34, Iss 2, Pp 309-319 (2015)
Druh dokumentu:	article
ISSN:	1857-5552 1857-5625
DOI:	10.20450/mjcce.2015.689
Popis:	The reactivity study of both the amino group and the aryl substituent of the newly synthesized 2-amino-5-(4-acetylphenylazo)-thiazole compound and its derivatives via various electrophilic reagents were performed to obtain the expected new bioactive chalcone, imine and pyrazole- thiazolidine derivatives. The synthesized compounds were chemically elucidated by analytical and spectral methods, and biologically evaluated upon screening in vitro and in vivo for their toxicity and antioxidant activity based on liver function enzymes.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/0db51bf42dc249d6b3ec6ff30b781002 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF