| Autor: |
Elaine S. Coimbra, Camila G. Almeida, Wilson V. Júnior, Roberta C. N. Dos Reis, Ana C. F. De Almeida, Luana S. M. Forezi, Mauro V. De Almeida, Mireille Le Hyaric |
| Jazyk: |
angličtina |
| Rok vydání: |
2008 |
| Předmět: |
|
| Zdroj: |
The Scientific World Journal, Vol 8, Pp 752-756 (2008) |
| Druh dokumentu: |
article |
| ISSN: |
1537-744X |
| DOI: |
10.1100/tsw.2008.100 |
| Popis: |
A number of lipophilic N-acyl-diamines and aldonamides have been synthesized and tested for their in vitro antiproliferative activity against Leishmania amazonensis and L. chagasi. Ribonamides, having one amino group, displayed good to moderate inhibition of parasite growth. The best result was obtained for compounds 10 and 15 with IC50 against L. chagasi below 5 μM. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
Plný text