| Autor: |
Sakue Masuda, Yoshinori Imamura, Ryuhei Jinushi, Jun Kubota, Karen Kimura, Makomo Makazu, Ryo Sato, Makoto Kako, Masahiro Kobayashi, Haruki Uojima, Chikamasa Ichita, Kazuya Koizumi |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
JGH Open, Vol 8, Iss 3, Pp n/a-n/a (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2397-9070 |
| DOI: |
10.1002/jgh3.13047 |
| Popis: |
Abstract Background and Aim The appropriate duration of antimicrobial therapy for acute cholangitis (AC) arising from multiple hilar biliary obstructions as opposed to simple obstruction in the extrahepatic bile duct has not been established. This study assessed the efficacy of the duration of antimicrobial treatments in the Tokyo Guidelines 2018 for AC based on the cause and site of obstruction. Methods This single‐center retrospective study involved patients with AC who underwent successful biliary drainage and completed a 7‐day or shorter antimicrobial treatment. Patients were categorized into three groups: Group 1, bile duct stone or benign obstruction; Group 2, simple biliary obstruction due to malignancy; and Group 3, multiple hilar biliary obstruction due to malignancy. The primary outcome was clinical cure rate, and the secondary outcomes were 3‐month recurrence rate and length of hospital stay. Results A total of 373 patients were selected. Patients in Group 3 were younger or had Charlson Comorbidity Index ≥4, and had fewer positive blood cultures. In Group 3, the clinical cure rate (87.1%) and 3‐month recurrence rate (32.3%) were less favorable than those in the other groups. In Group 1, the clinical cure rate was significantly higher (98.1%, P = 0.02) with a much lower 3‐month recurrence rate of only 3.4% (P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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